Department of Physics, Chemistry and Biology (IFM)

Cell viabilty on random and aligned PEDOT coated PCL is significantly more than pure PCL   electrospun micro fibres.   Hence, passive PEDOT coated PCL could be concluded as suitable   and reliable substrate for   in vitro   nerve regeneration, though enhanced neuronal differentiation   of NDCs and directed   extension of axons were seen and significantly similar on both.

Futhermore, active PEDOT coated PCL could be a potential substrate because of its conductivity which plays a vital role in neurotransmission.Subsequent studies on PEDOT coated PCL with voltage stimulation gives a conductive substrate for nerve regeneration which could serve   in vitro   model of cornea.

Further studies on different materials for better differentiation with contractile activity could help in developing a regenerative therapy for Myocardial infarction