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Carl-Fredrik Mandenius

Professor in Engineering Biology

Head of Division of Biotechnology

Mandenius is professor Engineering Biology at Linköping University since 1999 and head of the Division of Biotechnology. He is M.Eng. and D.Eng  in applied biochemistry and biotechnology from Lund University. His main research interests are bioprocess engineering, biosensor technology and biotechnology design. Recent topics developed in his research are conceptual design of bioproducts and bioprocesses, in vitro analytical methods for cell-based assays, analytical applications with pluripotent stem cells derived to cardiac and hepatic cells.

Recent publications

  • Bergström G, Christoffersson J, Zweigerdt R, Schwanke K, Mandenius CF (2015). Stem cell derived cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. Lab Chip 15, 3242-3249.
  • Bergström G, Nilsson K, Robinson N, Mandenius CF (2014). Macroporous microcarriers for introducing cells in a microfluidic chip. Lab Chip 14, 3502-3504.
  • Fritzsche M, Fritzsche J, Tegenfeldt JO, Mandenius CF (2014). A highly UV-transparent fused silica biochip for sensitive hepatotoxicity testing by autofluorescence. Biochip J. 8, 115-121
  • Darkins CL, Mandenius CF (2014). Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes. Chem. Eng. Res. Design 92, 1142–1152
  • Mandenius CF, Gustavsson R (2015) Mini-review: Soft sensors as means PAT in the manufacture of bio-therapeutics. J. Chem. Technol. Biotechnol. 90, 215-227.
  • Mandenius CF, Gustavsson R (2015) Mini-review: Soft sensors as means PAT in the manufacture of bio-therapeutics. J. Chem. Technol. Biotechnol. 90, 215-227.
  • Mandenius CF, Titchener-Hooker N (ed) (2013) Measurement, Monitoring, Modelling and Control (M3C) of bioprocesses. Advances in Biochemical Engineering and Biotechnology, Volume 132, Springer Verlag, Berlin, Germany
  • Mandenius CF (2012) Biomechatronics for designing bioprocess monitoring and control systems: Application to stem cell production. J. Biotechnol. 162, 430-440
  • Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy S. 2011. Cardiotoxicity testing using pluripotent stem cell derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J. Appl. Toxicol. 31, 191-205
  • Mandenius CF et al. 2011. Towards preclinical predictive drug testing for metabolism and hepatotoxicity by in vitro models derived from human embryonic stem cells: a report on the Vitrocellomics EU-project. Altern. Lab. Anim. (ATLA) 39 (2), 147-171


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Last updated: 02/18/16