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Recent Publications


Williams DJ ... Hyllner J, ... et al (2016). Comparability: manufacturing, characterization and controls. Regen. Med. 11, 483-491.

Gerlach I, Tholin S, Hass VC, Mandenius CF (2016). Operator training simulator for an industrial bioethanol plant. Processes 4, 34, 1-19.

Christoffersson J, Bergström G, Schwanke K, Kempf H, Zweigerdt R, Mandenius CF (2016). A microfluidic bioreactor for toxicity testing of stem cell derived 3D cardiac bodies. Bioreactors in Stem Cell Biology: Methods and Protocols (Ed. K Turksen), Springer Verlag, London.

Gaskell T, Englund MCO, Hyllner J (2016). Human embryonic stem cells. In: Regenerative Medicine, from Protocol to Patients (Ed. Steinhoff G), Springer Verlag, Germany

Roch P and Mandenius CF (2016).  On-line monitoring of downstream bioprocesses. Curr. Opin. Chem. Eng. 14, 112-220.

Mandenius CF (Editor). Bioreactors: Design, Operation and Novel Applications. Wiley-VCH, London, 2016

Mandenius CF (2016). Challenges for bioreactor design and operation. In: Bioreactors: Design, Operation and Novel Applications (Ed. CF Mandenius) . Wiley-VCH, London, 2016

van Noort D (2016). Bioreactors on a chip. In: Bioreactors: Design, Operation and Novel Applications (Ed. CF Mandenius) . Wiley-VCH, London, 2016

Mandenius CF and Gustavsson R (2016). Soft sensor design for bioreactor monitoring and control. In: Bioreactors: Design, Operation and Novel Applications (Ed. CF Mandenius) . Wiley-VCH, London, 2016

Mandenius CF (2016). Design-of-experiments for development and optimization of bioreactor media. In: Bioreactors: Design, Operation and Novel Applications (Ed. CF Mandenius) . Wiley-VCH, London, 2016


Hyllner J, Mason C, Wilmut I (2015). Cells: from Robert Hooke to cell thearpy - a 350 year journey. Phil. Trans. R. Soc. B 370, 20150017 http://dx.doi.org/10.1098/rstb.2015.0320

Mount NM, Ward SJ, Kefalas P, Hyllner J (2015). Cell-based therapy technology classifications and translational challenges. Phil. Trans. R. Soc. B 370, 20150017 http://dx.doi.org/10.1098/rstb.2015.0017

Gerlach I, Hass VC, Mandenius CF (2015). Conceptual design of an operating training simulator for a bio-ethanol plant. Processes (Open Access) 3, 664-683. www.mdpi.com/2227-9717/3/3/664

Bergström G, Christoffersson J, Zweigerdt R, Schwanke K, Mandenius CF (2015). Stem cell derived cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. Lab Chip 15, 3242-3249.

Bisson I, Green E, Sharpe M, Herbert C, Hyllner J, Mount N (2015) Landscape of current and emerging cell therapy clinical trials in the UK: current status, comparison to global trends and future perspectives. Regen. Med. 10, 169-179.

Barry J, Hyllner J, Stacy G, Taylor CJ, Turner M (2015) Settling up a haplobank: issues and solutions. Curr. Stem Cell Rep. DOI 10.1007/s40778-015-0011-7

Gerlach I, Mandenius CF, Hass VC, (2015). Operator training simulation for integrating cultivation and homogenisation in protein production. Biotechnol Reports 6, 91-99.

Gustavsson R, Lukasser C, Mandenius CF (2015). Control of specific carbon dioxide production in a fed-batch culture producing recombinant protein using a soft sensor. J. Biotechnol. 200, 41-49.

Mandenius CF, Gustavsson R (2015). Mini-review: Soft sensors as means for process analytical technology in the manufacture of bio-therapeutics. J Chem Technol Biotechnol  90, 215-227.

Johansson LBG, Simon R, Bergström G, Eriksson M, Prokop S, Mandenius CF, Heppne FL, Åslund AKO, Nilsson KPR (2015). An azide functionalized oligothiophene ligand - a versatile tool for multimodal detection of disease associated protein aggregates. Biosens Bioelectron 63, 204–211.


Paulsson D, Gustavsson R, Mandenius CF (2014). A soft sensor for bioprocess control based on sequential filtering of metabolic heat signals. Sensors (Open Access) 14, 17864-17882.

Bergström G, Nilsson K, Mandenius CF, Robinson N (2014) Macroporous microcarriers for introducing cells in a microfluidic chip. Lab Chip 14, 3502–3504.

Fritzsche M, Fritzsche J, Tegenfelt JO, Mandenius CF (2014). A highly UV-transparent fused silica biochip for sensitive hepatotoxicity testing by autofluorescence. Biochip J 8, 115-121.

Duong-Thi M-D, Bergström G, Mandenius CF, Fex T, Ohlson S (2014). Comparison of weak affinity chromatography and surface plasmon resonance in determining affinity of small molecules. Anal Biochem 461, 57-59.

Kaneko T, Nomura F, Hamada T, Abe Y, Takamori H, Sakakura T, Takasuna K, Sanbuissho A, Hyllner J, Sartipy P, Yasuda K (2014). On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip. Scientific Reports 4:4670.

Gerlach I, Brüning S, Gustavsson R, Mandenius CF, Hass VC  (2014).  Operator training in recombinant protein production using a structured simulator model. J Biotechnol 177, 53-59.

Boreström C, Simonsson S, Enochson L, Bigdeli N, Brantsing C, Ellerström C, Hyllner J, Lindahl A (2014). Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinical-grade cell source. Stem Cells Transl Med 3, 1-15.

Darkins CL, Mandenius CF (2014). Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes. Chem Eng Res Design 92, 1142-1152.

Gerlach I, Hass VC, Brüning S, Mandenius CF (2013). Virtual bioreactor cultivation for operator training and simulation: Application to ethanol and protein production. J Chem Technol Biotechnol 88, 2159–2168

Mandenius CF, Titchener-Hooker NJ (eds). Measurement, Monitoring, Modelling and Control of Bioprocesses. Adv Biochem Eng Biotechnol Volume 132, Springer Verlag, Berlin, 2013

Mandenius CF, Meyer T (2013) High-throughput screening assays to evaluate the cardiotoxic potential of drugs, in High-Throughput Screening Methods in Toxicity Testing (Editor Pablo Steinman), Wiley and Sons Inc., Hoboken, New Jersey (USA)

Li O, Tormin A, Sundberg B, Hyllner J, Le Blanc K, Schedling S (2013). Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoisis without suppressing immune functions: implications for off-the shelf ES-MSC therapies. PLoS ONE 8 (1), e55319

Gustavsson R, Mandenius CF (2013). Soft sensor control of metabolic fluxes in a recombinant fed-batch cultivation producing Green Fluorescent Protein. Bioproc Biosys Eng 36, 1375-1384


Mandenius CF (2012) Biomechatronics for designing bioprocess monitoring and control systems: Application to stem cell production. J Biotechnol 162, 430-440

Carrondo MJT, Alves PM, Carinhas N, Glassey J, Hesse F, Merten OW, Micheletti M, Noll T, Oliveira R, Reichl U, Staby A, Teixeira AP, Weichert H, Mandenius CF (2012) How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnol J 7, 1522-1529

Gernaey K, Baganz F, Franco-Lara E, Kensy F, Krühne U, Luebberstedt M, Marx U, Palmquist E, Schmid A, Schubert F, Mandenius CF (2012) Monitoring and control of microbioreactors: An expert opinion on development needs. Biotechnol J 7, 1308-1314

Mandenius CF (2012) Design of monitoring and sensor systems for bioprocesses using biomechatronic principles. Chem Eng Technol 35, 1412-142

Luttmann R, Bracewell DG, Cornelissen G, Gernaey KV, Glassey J, Hass VC, Kaiser C, Preusse C, Striedner G, Mandenius CF (2012) Soft sensors in bioprocesses. Status report and recommendation. Biotechnol J 7, 1040-1047

Mandenius CF, Björkman M (2012) Scale-up of bioreactors using biomechantronic design methodology. Biotechnol J 7, 1026-1039



Glassey J, Gernaey KV, Oliveria R, Striedner G, Clemens C, Schultz TV, Mandenius CF (2011) PAT for biopharmaceuticals. Biotechnol J 6, 369-377

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy S (2011) Cardiotoxicity testing using pluripotent stem cell derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol 31, 191-205

Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Björquist P, Carrondo MJT, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Küppers-Munther B, Müller-Vieira U, Noor F, Zeilinger K (2011) Towards preclinical predictive drug testing for metabolism and hepatotoxicity by in vitro models derived from human embryonic stem cells: a report on the Vitrocellomics EU-project. Altern Lab Anim (ATLA) 39, 147-171

Mandenius CF, Björkman M (2011) Biomechatronic Design in Biotechnology: a Methodology for Development of Biotechnology Products. John Wiley & Sons, Inc., Hoboken, New Jersey, USA

Mandenius CF (2011) Biomechatronic design for sensors. GIT Laboratory Journal, 15, 24-25

Bergström G, Mandenius CF (2010) Orientation and capturing of antibody affinity ligands: applications to surface plasmon resonance biochips . Sensors Actuators B 158, 265-270


Mandenius CF, Björkman M (2010) Mechatronic design principles for biotechnology product development. Trends Biotechnol 28, 230-236

Bracewell D, Gernaey KV, Glassey J, Hass VC, Heinzle E, Mandenius CF*, Olsson IM, Racher A, Staby A, Titchener-Hooker N (2010) Report and Recommendation of a Workshop on Education and Training for Measurement, Monitoring, Modelling & Control (M3C) in Biochemical Engineering. Biotechnol J 5, 359–367

Warth B, Rajkai G, Mandenius CF (2010) Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein. J Biotechnol 147, 37-45

Fritzsche M, Mandenius CF (2010) Cell-based sensor systems for toxicity testing using novel fluorescence spectroscopic approaches. Anal Bioanal Chem 398, 181-191

Brinck M, Mandenius CF, Skoglund A (2010) On-line predictions of aspen and birch bark contents in unbleached hardwood pulp, based on NIR spectroscopy and multivariate data analysis. Chemometrics and Intelligent Laboratory Systems 103, 53–58

Andersson H, Kågedal B, Mandenius CF (2010) Monitoring of troponin release from cardiomyocytes during exposure of toxic substances using surface plasmon resonance biosensing. Anal Bioanal Chem 398, 13951402

Andersson H, Steel D, Asp J, Dahlenborg K, Jonsson M, Kågedal B, Jeppsson A, Lindahl A, Sartipy P, Mandenius CF (2010) Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells. J Biotechnol 150, 175–181

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Last updated: 10/26/16