Dr. Ashutosh Tiwari
Ashutosh Tiwari is Associate Professor and Group Leader, Smart Materials and Biodevices at the world premier Biosensors and Bioelectronics Centre, Linköping University, Sweden; Editor-in-Chief, Advanced Materials Letters; Secretary General, International Association of Advanced Materials; a materials chemist and docent in the Applied Physics from Linköping University, Sweden. Dr. Tiwari is honoured as visiting professor at National Institute for Materials Science, Japan; guest Professor at University of Jinan, China; Adjunct Professor in the DCR University of Science and Technology, India; and Director, Vinoba Bhave Research Institute, India. Just after completed his doctorate degree, he joined as young scientist at National Physical Laboratory, India and later moved to University of Wisconsin, USA for postdoctoral research. He is actively engaged as reviewer, editor and member of scientific bodies around the world. Prof. Tiwari obtained various prestigious fellowships including JSPS (regular and bridge fellow), Japan; SSF & SI, Sweden; and Marie Curie, The European Commission. In his academic carrier, he has published over 350 articles, patents and conference proceedings in the field of materials science and technology. He edited/authored more than fifteen books on the advanced state-of-the-art of materials science with several publishers. He becamethe book series editor of Advanced Materials Series, working group member of the technology integration of TD1003, European Cooperation in Science and Technology and a founder member of Advanced Materials World Congress, Indian Materials Congress, famous international events of materials science and engineering. Dr. Tiwari is receipt of high-status 'The Nano Award', 'Innovation in Materials Science Award' and 'Advanced Materials Medal'.
Opening Projects for Master Students
Cutting edge biomedical devices: bioreactor, stimuli-responsive and intelligent carrier/scaffolds for bioelectronics, drug delivery, imaging, and tissue engineering
Integrated bio-edge, one of emerging frontiers in materials science and biomedical studies deals with induced conformational changes in biological structures at macro to nano levels. The model biochemical reactions have found applications in both analytical science and medical technology. Temperature-, pH-, magneto- and photo-switchable biodevices aim to design, construct and evaluate a new generation of products towards advanced application in fabrication of high-order dignostic devices with switchable bioelectronics and modulated biochemical processing.
Fabrication and design of nanobiosensors
The integration of biological or biologically inspired sensing elements with electronic transducers, which lies at the heart of biosensor technology, promises potential solutions to these multifarious diagnostic challenges. Considerable advances have been made recently in fusing biological sensing modules to electronic devices with the potential to create powerful nanoscaled biosensors. This is a newly emerging supra-disciplinary field with very significant commercial potential in the personalized product healthcare and biopharm sectors. Nanoscaled biosensors have not been exploited or commercialised because of technology deficits, but the diseases and lifestyles that affect our body systems occur first at the nanoscale for example any infection or disease in the body. Progress in this field would make significant contributions to advanced medical technology, bioelectronics, nanomaterials and nanotechnology, and lead to the construction of ultra-sensitive nano aptasensors for early diagnosis of cancers. Specifically, we intend to design/create bio-inspired smart nanosystems to develop novel nano- biosensors with high sensitivity and reproducibility for the diagnosis of various diseases. The aim of project is to develop cutting-edge medical nanodevices for early diagnosis of the diseases by improving the sensitivity and selectivity of sensors on the nanomaterials platform including nanoparticles, nanorods and graphene using range of transduces. The nanodevices could help to improve the efficacy of the treatment by the prognosis and detection of disease in the early stage.
Smart nanoscopic theranostic systems incorporate therapeutic agents, molecular targeting and diagnostic imaging capabilities that are emerging as the next generation of multifunctional nanomedicine to improve the therapeutic outcome. In the recent years, functional core-shell technology has become a fundamental tool for theranostic devices. The basic insights of using responsive magnetic nanoparticles as a smart metal core serve as magnetic resonance imaging (MRI) and hyperthermic functions in module. The smart magnetic drug nanocarrier allows cells adhesion, proliferation and differentiation with the triggered drug release and monitoring features.
Molecularly imprinted polymer (MIP) sensors
The molecularly imprinted polymers (MIPs) have attracted much attention due to their multifarious affinity such as in sensors, separations, catalysis, drug delivery and waste water management. MIPs have the ability to mimic biological functions through their three-dimensional cavities with specific size, shape, and functionality for mimetic recognition of target molecules and have already been applied for interesting applications such as the separation and recognition of glucose, cholesterol, hemoglobin, peptides, proteins, antibodies; and DNA. We investigate fabrication and characteriasations MIP sensors for real time monitoring of target biomolecules for example glucose, cholesterol and biomarkers of fetal diseases.
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List of Projects
1. Project Title: “Intelligent nanobioreactors for auto-switchable bio-catalysis"
Grant No: VR- 2011-6058357
Budget: 4 million SEK
Funding agency: Swedish Research Council
Summary: Nanobioreactors are advanced devices realised by the integration of nanobiotechnology and intelligent nanomaterials. Due to their ultimately small size, high surface area and simulation capacity, they are emerging as a versatile platform for building a new generation of ultra-sensitive and selective nanodevices, offering us new tools to tackle key medical, energy supply and environmental issues.
2. Project Title: “Stimuli-responsive zipper-like nanobioreactors”
Grant No: PIIF-GA-2010-254955
Budget: € 181, 103. 20
Funding agency: FP7, European Union
Summary: The proposal aims to design nanobioreactors capable of reversely responding through swelling/shrinking mechanism within the shell network, which is conceptually comparable to a switch, opening or closing, depending on the external environment.
3. Project Title: “Auto-switchable aptasensors for the early stage diagnosis of liver cancer"
Grant No: IGEN/LiU/2012-15
Budget: 800,000.00 SEK
Funding agency: Integrative Regenerative Medicine (IGEN) Center
Summary: The goal of project is to fabricate of whole cell detection of liver cancer cells using smart aptasensors.
4. Project Title: “Wearable sensors with nanoengineered smart architecture"
Grant No: LIST/LiU/2012-13
Budget: 350,000.00 SEK
Funding agency: Linköping Centre for Life Science Technologies
Summary: We proposed to development of wearable glucose sensors based on contact lens using optical transduce.
- Sweta Thakur (PhD student)-Shoolini University, India
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