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Role of TRPV1 channel and P2Y1 receptor in Ca2+ signalling in β-cells: A study by single cell microfluorometry

Increase in the intracellular Ca2+ concentration ( [Ca2+]i ) in β-cells triggers insulin exocytosis. Among the Ca2+ channels, and receptors present in the plasma membrane, transient receptor potential (TRP) channels, and P2Y1 receptors are currently of great interest. The mechanism by which the extracellular Adenosine diphosphate ribose (ADPr) increases the [Ca2+]i is unknown. Our aims were to study the involvement of TRP channels in tolbutamide induced [Ca2+]i increase and to identify the surface receptor that is activated by ADPr.

Responsible for this page: Agneta Johansson
Last updated: 05/21/11