The Ingemar Kvarnström Group
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Synthesis of potential protease inhibitors:
Proteases are enzymes capable of restructuring peptides and proteins by specific hydrolysis and are therefore powerful mediators for health and disease. There are five different classes of proteases, classified according to the most significant functional group in the active site of the enzyme. Design and synthesis of inhibitors and screening for efficient and selective inhibitors of key proteases have become an attractive and powerful course for new drug development. This is an area of fundamental importance to the pharmaceutical industry.
Structure based drug design has been used in the search for potent and selective drug candidates. An important part of this is to find the minimum necessary chemical features for binding to a particular protease. Methods for screening of potential inhibitors are available and it is possible to screen large libraries of single compounds to identify lead compounds. Design and synthesis of inhibitors have been studied against the following proteases: HIV-1 protease, Hepatit C protease, Malaria parasite proteases, Thrombin and γ–Secretase (Alzeimers disease). The research projects are done in collaboration with the University of Stockholm, BMC, Uppsala and Medivir AB, Huddinge.
Responsible for this page: Maria Sunnerhagen
Last updated: 03/30/11