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Karin Enander, Ph D

Associate Professor in Molecular Physics, especially Biomolecular Analysis

Senior lecturer

Director of Centre in Nanoscience and Technology (CeNano)

Division of Molecular Physics
Department of Physics, Chemistry and Biology (IFM)
Linköping University
SE-581 83 Linköping, Sweden

phone: +46-13-282359
fax: +46-13-137568
email: karin.enander@liu.se

2014- Director of Centre in Nanoscience and Technology (CeNano)

2011- Associate professor and senior lecturer at the Division of Molecular Physics; Department of Physics, Chemistry and Biology; Linköping University; Linköping; Sweden.

2009-2014 Director of Linköping Initiative in Life Science Technologies (LIST)

2006-2010 Assistant professor at the Division of Molecular Physics; Department of Physics, Chemistry and Biology; Linköping University; Linköping; Sweden.

2005 Postdoc at Ecole Supérieure de Biotechnologie de Strasbourg; Université Louis Pasteur; Strasbourg; France.

2004 Postdoc at the Division of Organic Chemistry; Department of Chemistry; Uppsala University; Uppsala; Sweden.

2003 Ph D in Chemistry from the Division of Chemistry; Department of Physics, Chemistry and Biology; Linköping University; Linköping; Sweden.

Size: 8.7K bytes Modified: 4 March 2010, 16:12

1999 M Sc in Molecular Biotechnology, Uppsala University, Uppsala, Sweden.

Research

Main focus

Design and interaction analysis of proteins and peptides, mainly for sensing purposes.

Activities

  • Peptide and protein production: Chemical synthesis of polypeptides and eukaryotic protein expression (Pichia pastoris)
  • Biomoleuclar interaction analysis (mainly by means of surface plasmon resonance and fluorescence spectroscopy techniques)
  • Bioassay and protein microarray design
  • Design of molecular sensor elements and synthetic receptors
  • Nanoparticle-based supramolecular chemistry and plasmonic fluorescence enhancement
  • Surface design for cell adhesion studies
  • Development of protein immobilization strategies

Publications

Halling Linder C, Enander K, Magnusson P: "Glycation contributes to interaction between human bone alkaline phosphatase and collagen type I" Calcif Tissue Int 98:284–293 (2016) Abstract

Aronsson C, Dånmark S, Zhou F, Öberg P, Enander K, Su HB, Aili D: "Self-sorting heterodimeric coiled coil peptides with defined and tuneable self-assembly properties" Scientific Reports 5:14063 (2015) Abstract

Petrone L, Aldred N, Emami K, Enander K, Ederth T, Clare AS: "Chemistry-specific surface adsorption of the barnacle settlement-inducing protein complex" Interface Focus 5:20140047 (2015) Abstract

Selegård R, Enander K, Aili D: "Generic phosphatase activity detection using zinc mediated aggregation modulation of polypeptide-modified gold nanoparticles" Nanoscale 6:14204-14212 (2014) Abstract

Martinsson E, Shahjamali MM, Enander K, Boey F, Xue C, Aili D, and Liedberg B: "Local refractive index sensing based on edge gold-coated silver nanoprisms" Journal of Physical Chemistry C 117: 23148-23154 (2013) Abstract

Ericsson EM, Enander K, Bui L, Lundström I, Konradsson P, and Liedberg B: "Site-specific and covalent attachment of His-tagged proteins by chelation assisted photoimmobilization: A strategy for microarraying of protein ligands" Langmuir 29:11687-11694 (2013) Abstract

Kanmert D, Kastbom A, Almroth G, Skogh T, Enander K, and Wetterö J: "IgG rheumatoid factors against the four human Fc-gamma subclasses in early rheumatoid arthritis (the Swedish TIRA project)" Scandinavian Journal of Immunology 75:115-119 (2012) Abstract

Kanmert D, Brorsson A-C, Jonsson B-H, and Enander K: "Thermal induction of an alternatively folded state in human IgG-Fc." Biochemistry 50:981-988 (2011) Abstract

Choulier L and Enander K: "Environmentally sensitive fluorescent sensors based on synthetic peptides." Sensors 10: 3126-3144 (2010)

Kanmert D, Enocsson H, Wetterö J, Kastbom A, Skogh T, and Enander K: "Designed surface with tunable IgG density as an in vitro model for immune complex mediated stimulation of leukocytes." Langmuir 26: 3493–3497 (2010) Abstract

Aili D, Selegård R, Baltzer L, Enander K, and Liedberg B: "Colorimetric protein sensing by controlled assembly of gold nanoparticles functionalized with synthetic receptors." Small 5:2445-2452 (2009) Abstract

Andersson O, Nikkinen H, Kanmert D, and Enander K: "A multiple-ligand approach to extending the dynamic range of analyte quantification in protein microarrays. " Biosensors and Bioelectronics 24:2458-2464 (2009) Abstract

Carlsson J, Gullstrand C, Westermark G, Ludvigsson J, Enander K, and Liedberg B: "An indirect competitive immunoassay for insulin autoantibodies based on surface plasmon resonance." Biosensors and Bioelectronics 24:882-887 (2008) Abstract

Enander K, Choulier L, Olsson L, Yushchenko D, Kanmert D, Klymchenko A, Demchenko A, Mély Y, and Altschuh D: "A peptide-based, ratiometric biosensor construct for direct fluorescence detection of a protein analyte." Bioconjugate Chemistry 19:1864-1870 (2008) Abstract

Aili D, Enander K, Baltzer L, and Liedberg B: "Assembly of polypeptide-functionalized gold nanoparticles through a heteroassociation- and folding-dependent bridging" Nano Letters 8:2473-2478 (2008) Abstract

Aili D, Tai F-I, Enander K , Baltzer L, and Liedberg B: "Self-assembling fibers and nano-rings from disulphide-linked helix-loop-helix polypeptides." Angewandte Chemie, Int. Ed. 47 :5554-5556 (2008)

Aili D, Enander K, Rydberg J, Nesterenko I, Björefors F, Baltzer L, and Liedberg B: "Folding induced assembly of polypeptide decorated gold nanoparticles." Journal of the American Chemical Society 130 :5780-5788 (2008) Abstract

Aili D, Enander K, Rydberg J, Lundström I, Baltzer L, and Liedberg B: "Aggregation-induced folding of a de novo designed polypeptide immobilized on gold nanoparticles." Journal of the American Chemical Society 128 :2194-2195 (2006) Abstract

Andersson T, Lundquist M, Dolphin G T, Enander K, Jonsson B H, Nilsson J W, and Baltzer L: "The binding of human carbonic anhydrase II by functionalized folded polypeptide receptors." Chemistry and Biology 12:1245-1252 (2005) Abstract

Enander K, Aili D, Baltzer L, Lundström I, and Liedberg B: "Alpha-helix-inducing dimerization of synthetic polypeptide scaffolds on gold." Langmuir 21:2480-2487 (2005) Abstract

Enander K, Dolphin G T, and Baltzer L: "Designed, functionalized helix-loop helix motifs that bind human Carbonic Anhydrase II – a new class of synthetic receptor molecules" Journal of the American Chemical Society 126 :4464-4465 (2004) Abstract

Enander K, Dolphin G T, Liedberg B, Lundström I, and Baltzer L: "A versatile polypeptide platform for integrated recognition and reporting – affinity arrays for protein-ligand interaction analysis" Chemistry – A European Journal 10:2375-2385 (2004) Abstract

Enander K, Andersson L K, Dolphin G T, Liedberg B, Lundström I, and Baltzer L: "Designed, folded polypeptide scaffolds that combine key biosensing events of recognition and reporting" Journal of Organic Chemistry 67:3120-3123 (2002)

Riepl M, Enander K, Liedberg B, Schaferling M, Kruschina M, Ortigao F: "Functionalized surfaces of mixed alkanethiols on gold as a platform for oligonucleotide microarrays" Langmuir 18:7016-7023 (2002)

Svedhem S, Enander K, Karlsson M, Sjöbom H, Liedberg B, Löfås S, Mårtensson L-G, Sjöstrand S-E, Svensson S, Carlsson U, and Lundström I: "Subtle differences in dissociation rates of interactions between destabilized human carbonic anhydrase II mutants and immobilized benzenesulfonamide inhibitors probed by a surface plasmon resonance biosensor" Analytical Biochemistry 296:188-196 (2001) Abstract

Conferences and workshops (oral presentations and proceedings)

Ericsson E M, Bui L, Lundström I, Konradsson P, Liedberg B, and Enander K: Controlled orientation and covalent attachment of proteins on biosensor surfaces by chelation assisted photoimmobilization" Oral presentation, 3rd International Conference in Bio-Sensing Technology, Sitges, Spain, 2013

Enander K: "Protein analyte quantification: concept development" Oral presentation, Taiwan-Sweden Workshop on Nanoscience and Technology, Chi-TouTaiwan, 2009

Enander K: "Strategies for improved target quantification in protein microarrays" Invited talk, 2nd Label Free Array Workshop, Paris, France, 2008

Aili D, Han H S, Enander K, Baltzer L, and Liedberg B: "Controlled assembly of gold nanoparticles using de novo designed polypeptide scaffolds" Proceedings of SPIE 6885: 688506 (2008)

Aili D, Enander K, Baltzer L, and Liedberg B: "Synthetic de novo designed polypeptides for control of nanoparticle assembly and biosensing" Biochemical Society Transactions 35:532-534 (2007)  

Enander K, Dolphin G T, Lundström I, Liedberg B, and Baltzer L: "De novo designed helix-loop-helix polypeptides – a structure-function-based design strategy for microarray and biosensor applications" Oral presentation, 1st World Congress on Synthetic Receptors, Lisbon, Portugal, 2003

Enander K, Dolphin G T, Löfdahl M, Lundström I, Liedberg B, and Baltzer L: "Designed, folded polypeptides as functional units in surface-based biosensors – versatile scaffolds connecting recognition and reporting" Oral presentation, Europt(r)ode VI, Manchester, UK, 2002  

Teaching

Advanced level

2014- Responsible for the CDIO project course "Materials in Medicine", 6 hp

2006- Course developer and responsible for advanced level course "Proteomics", 6 hp

2006- Guest lecturer in advanced level courses "Biomolecular design", "Biosensor technology", "Methods in biotechnology", "Advanced immunology", "Supramolecular Chemistry", "Modern Sensor Systems"

1999-2002: Assistant in "Principles of Physics", "Biosensor technology", "Surface science", "Biomaterials"

PhD level

Fluorescence spectroscopy, 8+4 hp

Miscellaneous

2015- Member of the appointment board at the Engineering Faculty (LiTH)

2012- Member of the Saco-S board at LiU

2009- Member of the programme board for chemistry, biology and biotechnology at the Engineering Faculty (LiTH), with responsibility for the Engineering Biology programme

2007- Member of the LiU board for the Swedish Association of Graduate Engineers (Sveriges Ingenjörer)

2009-2014: Director of Linköping Initiative in Life Science Technologies (LIST)

2007-2009: Involved in the establishment of LiU Junior Faculty and head of the LiTH Junior Faculty steering group (2008-2009)

2005-2010: Project leader of the LiU contribution to "CAREMAN - HealthCARE by Biosensor Measurements And Networking", an EU-funded Integrated Project within the 6th Framework Programme


Responsible for this page: Erik Martinsson
Last updated: 06/28/16