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Self Assembled Monolayers (SAMs)

SAMs are ordered molecular assemblies, and can be prepared by various methods. We use thiol-based SAMs on gold substrates extensively, both for controlling surface properties, or for fundamental studies of self-assembly. A major advantage is the simplicity of preparation; immersion of a gold substrate into a thiol solution leads to spontaneous adsorption and surface coverage within a few minutes. To obtain well-ordered crystalline layers, you usually just have to wait overnight.

We also use silanization for SAMs on oxides (glass, silicon wafers), to control surface chemistry.


Further reading about Self Assembled Monolayers.

Long Chain Alkylthiolate Assemblies

SAMs on gold formed by long chain alkanethiols containing moieties of oligo(ethylene glycol) (OEG) have become an attractive strategy in designing biointerfaces. This type of SAMs is proved to be a reliable platform for engineering of protein and cell-specific interfaces. The remarkable popularity of this particular system relies on the relative structural simplicity of the constituent compounds, the ease of preparation, and the structural robustness of the obtained SAMs.



Our goal is to undertake a systematic investigation of this type of structurally complex SAMs. These compounds were synthesized to reveal the role of the length of the terminal alkyl chain via introducing its deuterated analogs.

Tethered lipid Membrane Formation on Assemblies

This study is to develop a flexible and stable self-assembled monolayer (SAM) system which can be applied to the design of bio-mimetic interfaces for the assembly of supported lipid membranes (SLMs).

Our SLM model system is a mixed SAM consisting of a range of surface concentration of the anchors with a hydrophobic tail dispersed in a hydrophilic matrix .

Responsible for this page: Erik Martinsson
Last updated: 01/13/15